---
title: What is the best way to supplement NAD+? - Limitless Mindset
description: There are several ways, both practical and economical, to supplement NAD+, the “immortality molecule.”
author: Jonathan Roseland
url: https://www.limitlessmindset.com/blog/1614-supplement-nad-nmn
---

# What is the best way to supplement NAD+?

Ⓒ By **Jonathan Roseland**

Applied Neuroscience Strategist, K-Selected Biohacker, Tantric husband, Promethean peaceful parent, Adventuring philosopher, Raconteur, and Author. He spent +14 years researching the intersection of human performance enhancement and advanced personal growth in his obsessive quest - spanning three continents - to find real-life "NZT-48."

---

## *Is **NAD+** the Immortality Molecule?*

Listening to people like world-renowned anti-aging researcher David Sinclair Ph.D. of Harvard you certainly might think so. The scientists who have looked the hardest at NAD+ think it may be the key to unlocking lifespans of greater than 120 years. It’s a very special molecule that has everything to do with why we age and the corresponding declines we experience in quality of life and mind.

[Subscribe to the Limitless channel](https://www.limitlessmindset.com/videos)

Why is NAD+ so interesting to those crazy enough to think that we may one day live as long as we want to?

- **NAD+ is a crucial cofactor of epigenetic function**. Epigenetics is our genome’s capacity to turn on or off the right genes at the right time.
- **NAD+ supports Mitochondrial function**. Mitochondria are the powerhouse of the cell, the underlying energy generation system of the body.
- Decreasing NAD+ level is also *associated with age-related DNA damage*, according to a [2019 *Therapeutic Applications* paper](https://www.ncbi.nlm.nih.gov/pubmed/30669679). In the toxic soup of modernity, our DNA struggles to replicate itself perfectly, the shoddier the replication the more risk of cancer. NAD+ protects the DNA from all the nasty toxins and free radicals that threaten our health.
- NAD+ tunes your immune system *like a master tuner tuning a grand piano*. It can also modulate down the immune system which mitigates various autoimmune disorders.
- NAD+ comes from Vitamin B3 which is found in space. NASA scientists have actually identified Vitamin B3 in meteorites, adding credence to the *Panspermia theory* for the emergence of life on this planet.

Dr. Philip Milgram of the NAD Treatment Center in San Diego, California believes...

> "NAD will turn out to be one of the greatest advances in medical science since Fleming invented penicillin."

A big question that anti-aging pragmatists, holistic health practitioners, and biohackers are asking is...

*What is the safest, most effective, and most practical way to supplement NAD+?*

NAD+ itself is not orally bioavailable, if you want to supplement it directly you need to get it injected intravenously, right in your bloodstream. Which is pricey ([about $600](https://www.vice.com/en_us/article/bn3vmq/nad-plus-brain-reboot-infusion-injection)) and needs to be done in a NAD clinic by a professional. Fortunately, there are several other ways to supplement NAD+ that are a lot more practical and economical.

![NMN NR NAD](https://www.limitlessmindset.com/images/stories/blog/NMN_NR_NAD_750.png)

Here we’ll compare them so you can decide which represents the best *biological bang for your buck*...

## **Niacin** (Vitamin B3)

![Naicin Vitamin B3](https://www.limitlessmindset.com/images/stories/blog/Naicin_Vitamin_B3-750.png)

Of all the B-Vitamins this is the one whose history I found both fascinating and *tragic*. It was experimented with by Abram Hoffer, Ph.D., MD. a real visionary healer who played a role in founding Alcoholics Anonymous. I find B3 tragic because Dr. Hoffer believed it had real potential to heal the trauma of a hurting world, but the medical and [scientific institutions with their billions and billions of dollars in public funding](https://www.limitlessmindset.com/books/708-rigor-mortis#Funding) never cared to really explore its promise.

- Around the internet, you’ll find a bunch of fancy Mitochondrial function supplements but B vitamins like B3 are actually one of the best things you can supplement to support your Mitochondria.
- [Its users consistently report](http://www.limitlessmindset.com/nootropic-ingredients/328-vitamin-b3-niacin#Hunger) that B3 increases appetite. You’ll be eating more and maybe experience food cravings. If you’re trying to gain weight B3 is a good Vitamin to take.
- **The problem with Vitamin B3** is that it causes an unpleasant skin *flush*, it makes your skin visibly red and you *feel* uncomfortably hot. You can buy *non-flush* B3 but its efficacy is debated by the experts.

**Dosage**: 500 - 1500 milligrams daily
**Cost**: It’s very inexpensive, [$12 for a 500 milligram 240 capsule supply](https://www.limitlessmindset.com/Niacin), between an 8-month and 2-and-a-half-month supply.

## **NR** (Nicotinamide Riboside)

![Nicotinamide Riboside molecule](https://www.limitlessmindset.com/media/reviews/photos/original/5a/8b/2a/vitamin-b3-niacin-10-1710148844.png)

NIAGEN® is a patented and popular supplemental form of NR that has been researched at Cambridge University, Northwestern University, and Duke University. While a newer discovery in the anti-aging field, there are five [NR human clinical trials](https://www.ncbi.nlm.nih.gov/pubmed/?term=%22Nicotinamide+Riboside%22).

- As you can see from the NAD+ metabolism diagrams, NR is two steps removed from NAD+.
- At 300 milligrams daily NR increases NAD by 40%-50% in just 8 weeks.
- The sentiment among users seems to be that it does improve health noticeably but doesn’t have an energizing or stimulating immediate effect.

**Dosage**: 300 - 900 milligrams daily
**Cost**: The best value NR is [ninety 300 milligram capsules for $120](https://www.limitlessmindset.com/Nicotinamide-Riboside), a 1 - 3 month supply.

## **NMN** (Nicotinamide Mononucleotide)

![NMN (Nicotinamide Mononucleotide)](https://www.limitlessmindset.com/media/reviews/photos/original/a2/f6/d7/nmn-11-1650386330.jpg)

NMN while newer on the anti-aging scene has attained much acclaim by scientists and self-experimenters alike. It’s currently undergoing a human clinical trial in Japan.

- NMN is one step removed from NAD+, which it converts directly into.
- In regards to epigenetics, NMN activates the Sirtuin SIRT3 while [NR does not](https://scholar.google.com/scholar_lookup?journal=FASEB+J.&title=NAD++replacement+therapy+with+nicotinamide+riboside+does+not+improve+cardiac+function+in+a+model+of+mitochondrial+heart+disease&author=A.R.+Stram&author=P.M.+Pride&author=R.M.+Payne&volume=31&publication_year=2017&pages=602.15&).
- In a thorough sentiment analysis of the numerous anecdotes posted around the internet, I found NMN frequently described a classic Nootropic. [Two-thirds of Biohackers who responded to a survey](https://www.longecity.org/forum/topic/106948-nmn-biohacker-survey) agreed that it had *Nootropic effects (enhanced cognition, motivation and wakefulness).*

**Dosage**: 250 - 1000 milligrams daily
**Cost**: [Sixty 125-milligram capsules are $50](https://www.limitlessmindset.com/NMN), a 1-month to 1-week supply. Powdered NMN is even more affordable, [15 grams for $69](https://www.limitlessmindset.com/NMN-Powdered), 2 months - 15 days.

**To me, NMN is most appealing because of its**...

- Reasonable cost (powdered it’s less expensive than NR).
- Lack of negative side effects.
- And purported Nootropic effect; it’s a doubly good value if it both empowers my health and enhances my productivity.

## Sources of lab-tested pure NMN

## **What people are saying** about NMN’s antiaging effects...

[*57 going on 30 years old* - D. Speight](https://amzn.to/36pRTDl)

> “I may be the "youngest looking" 57 year old in Florida, but my body rarely feels like the 30 year old it resembles. When I read a few of the reviews about how quickly one could feel the results, I was skeptical. Not anymore! So the supplement option was already appealing to me. While I don't expect this to be an instant "fountain of youth," I'm optimistic it might come close in the long term.”

[*Want to feel younger with a boost of energy?* - Angelo](https://amzn.to/36jZDqx)

> “Infinite Age's PURE NMN supplement should be included in anyone's supplement regimen. I noticed clearer thoughts, increase energy levels, and improved recovery time. I am half a century old and being able to keep pushing throughout the everyday grind, it allows me to reach my goal of retirement much sooner; Infinite Age PURE NMN is one supplement to give a try.”

[*Fantastic Product, Great Effects* - Logan Tibbetts](https://amzn.to/2rwv3eE)

> “I have many years of experience trying a broad range of supplements, and so I have a lot of experience testing for effects and avoiding placebo, as well as many points for comparison. When starting, I was expecting a slight increase in energy or mild effects on my cognition. Instead, I have felt a substantial boost of (non-stimulating) energy, meaningfully improved clarity and quality of my thoughts, brightened mood, and most surprising to me, a pretty noticeable reduction in the day-to-day aches and pains that I, unfortunately, live with. Overall, I have been pleasantly surprised and impressed with Infinite Age's NMN.”

[*Didn’t expect it to work so quickly!!* - Eric G](https://amzn.to/38tstGS)

> “I have tried many supplements over the years and have yet to come across something as profound as this!!! Within about 1 hour out of nowhere, I felt this sense of positivity and just overall felt great. Something I couldn't explain as I never just felt "good" without being able to point out exactly why of how. I feel naturally energetic and the normal nagging pain in my neck isn’t there...”

Originally published on [InfiniteAgeCo.com](https://infiniteageco.com/blogs/news/what-is-the-best-way-to-supplement-nad)

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