--- title: "Thyronine \"T2\" - Top 9 Benefits of this Thyroid Biohack - Limitless Mindset" description: This active thyroid hormone supplement is turning heads in the bodybuilding and fitness world as it superpowers metabolism and accelerates fat loss. author: Jonathan Roseland url: https://www.limitlessmindset.com/nootropic-ingredients/1615-thyronine --- ![Thyronine "T2" - Top 9 Benefits of this Thyroid Biohack](https://www.limitlessmindset.com/data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==) # Thyronine [![Thyronine](https://www.limitlessmindset.com/data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)](https://www.limitlessmindset.com/media/reviews/photos/original/24/da/35/thyronine-90-1712242936.webp "Thyronine") Ⓒ By **Jonathan Roseland** Applied Neuroscience Strategist, K-Selected Biohacker, Tantric husband, Promethean peaceful parent, Adventuring philosopher, Raconteur, and Author. He spent +14 years researching the intersection of human performance enhancement and advanced personal growth in his obsessive quest - spanning three continents - to find real-life "NZT-48." --- ## **Top 9 benefits of Thyronine "T2"** This active [thyroid hormone supplement](https://www.limitlessmindset.com/Thyronine) is turning heads in the bodybuilding and fitness world as it superpowers metabolism and accelerates fat loss. **3,5-diiodo-L-thyronine**, which I’ll refer to from now on as *T2*, is discussed in [over 120 scientific papers on PubMed](https://www.ncbi.nlm.nih.gov/pubmed/?term=%223%2C5-diiodo-L-thyronine%22) and has been the subject of a human clinical trial. Here, I’ll break down its benefits and some of the science done on it. [Increases Metabolism](https://www.limitlessmindset.com/#Metabolism) [Fat Loss](https://www.limitlessmindset.com/#Fat) [Prevents Insulin Resistance](https://www.limitlessmindset.com/#Insulin) [Thyroid Support](https://www.limitlessmindset.com/#Thyroid) [Skin Hack](https://www.limitlessmindset.com/#Skin) [Energizing Nootropic](https://www.limitlessmindset.com/#Nootropic) [Mitochondrial Support](https://www.limitlessmindset.com/#Mitochondrial) [Cancer Preventative](https://www.limitlessmindset.com/#Cancer) [Promotes Healthy Libido](https://www.limitlessmindset.com/#Libido) [Risk Grade](https://www.limitlessmindset.com/#Risk) [Sources](https://www.limitlessmindset.com/#Sources) [Conclusion](https://www.limitlessmindset.com/#Conclusion) This article is mostly going to focus on decoding what the human studies are saying about Thyronine and how this squares up with the anecdotal experiences of Biohackers online. For more of my own personal experiences, thoughts, and comparisons, please see the written and video reviews in the sidebar. ![https://www.limitlessmindset.com/images/Infographics/t2-thyronine-metabolic-biohack-overview-infographic-1280.webp?time=1](https://www.limitlessmindset.com/images/Infographics/t2-thyronine-metabolic-biohack-overview-infographic-1280.webp?time=1) ##  Increases **Metabolism** ![](https://www.limitlessmindset.com/images/stories/blog/metabolism-high-750.png) One of the main effects of T2 is increasing metabolism. This means that you’ll burn more calories faster. If you’re an avid exerciser or lift weights often, you probably eat a bit more, but you probably don’t want those calories going to your tummy and covering up your six-pack. The major difference between a Corolla and a Corvette is that one consumes fuel faster, producing a lot more power. No matter how much gas you put in the Corolla, it won’t go any faster. As an athlete, a bodybuilder, an entrepreneur, a professional, or just a health-conscious person, would you rather be more like a Corolla or a Corvette? If it’s the latter, T2 will empower your metabolism for peak performance. While fully legal and non-prescription, it’s a secret weapon of some rather large and intimidating bodybuilders, we’ll call them *T2erminators*. ##  **Fat** Loss ![](https://www.limitlessmindset.com/images/stories/blog/obesity_fat_icon.png) Often, as we age, our metabolism slows, and we put on pounds. We go to the gym and exercise, we diet, but the pounds stick around on persistent fat sites, like our bellies. T2 is a potent accelerator of fat loss. [19 scientific papers](https://www.ncbi.nlm.nih.gov/pubmed/?term=%223%2C5-diiodo-L-thyronine%22+Fat) delve into its mechanisms driving fat loss. - It increases conversion from the problematic white adipose tissue into brown adipose tissue. - From a 2015 study published [in PLOS One](https://www.ncbi.nlm.nih.gov/pubmed/25658324): *[T2] a thyroid hormone derivative, is capable of increasing energy expenditure, as well as preventing high fat diet-induced overweight and related metabolic dysfunction.* ##  Prevents **Insulin Resistance** ![](https://www.limitlessmindset.com/images/stories/blog/Insulin_resistance-800.png) If you have a family history of diabetes and obesity, you want to be vigilant about developing insulin resistance. Diet has a lot to do with this, of course, but if a personal genotyping report reveals that you have the apoE4 or any number of other problematic [diabetes-predicting genes](https://www.limitlessmindset.com/blog/452-problematic-gene-alleles#Diabetes) it would be really smart for you to supplement T2 which maintains healthy insulin sensitivity. A [2011 animal study](https://www.ncbi.nlm.nih.gov/pubmed/21926273) concluded... > T2, by activating SIRT1, triggers a cascade of events resulting in improvement of the serum lipid profile, prevention of fat accumulation, and, finally, prevention of diet-induced insulin resistance. ##  **Thyroid** Support ![Thyroid throat animation 750](https://www.limitlessmindset.com/images/stories/blog/Thyroid_throat_animation_750.jpg) Our livelihood and vigor rely fundamentally on the Thyroid, the function or dysfunction of this small organ in our necks, and the hormone it secretes throughout our bodies determines much about our quality of life. T2 is a precursor to thyroid hormone; it does not feed you excess hormone that’s going to put you into hormonal imbalance. T3 or T4 are more direct precursors to Thyroid hormone, and they have an even greater effect on metabolism, but there’s some concern with them upregulating the hormone too much. T2 feeds you the building blocks that your Thyroid needs to meet your body’s demands. A [recent Italian paper](https://www.ncbi.nlm.nih.gov/pubmed/30090086) identifies it as a *Novel Thyroid Hormone Metabolite*: > Over 30 years of research has demonstrated that 3,5-diiodo-L-thyronine (3,5-T2), an endogenous metabolite of thyroid hormones, exhibits interesting metabolic activities. Jimmy, a *T2erminator*, reported... > Great stuff - After a couple of weeks I noticed a HUGE difference in my metabolism. Thyroburn gave me more energy and completely jump started my thyroid. Awesome product. It could be a preventative of Thyroid disorders like Hashimoto's disease, goiter, Graves' disease, and thyroid nodules. ## **Skin** Hack ![Skin hack thyronine](https://www.limitlessmindset.com/images/stories/blog/Skin_hack_thyronine.jpg) For the vain, Thyroid downregulation is problematic; it results in conspicuously unhealthy skin - *think of Gollum in The Lord of the Rings*. Upregulating Thyroid hormone may restore such vibrancy and color to your skin that you no longer need to use filters on Instagram! T2 is a safe way to do that. ##  Energizing **Nootropic** ![energizing nootropic 750](https://www.limitlessmindset.com/images/stories/blog/energizing_nootropic-750.jpg) Nootropics are a *secret weapon* of high-performing entrepreneurs, students, and professionals. Nootropics give you an uptick in energy, motivation, and brainpower. The mechanism of T2 puts it more in the category of being a motivational Nootropic than a cognition-enhancing one. If you’re like many *T2erminators*, it will just give you loads of energy to get stuff done. With many Nootropics, you’ll develop a tolerance over time, or you need to implement a cycling strategy to avoid exhausting a particular neurotransmitter pathway. With T2, these are not concerns, as it just feeds the underlying energy generation system of the body. A [collaborative European study](https://www.ncbi.nlm.nih.gov/pubmed/24386638) identified that its Mitochondrial respiratory mechanism had a downstream effect as an antidepressant. ##  **Mitochondrial** Support ![mitochondria](https://www.limitlessmindset.com/images/stories/blog/mitochondria.png) T2’s Nootropic effect is probably due to its mitochondria-empowering mechanisms. The Mitochondria are the powerhouse of the cell, the underlying energy generation system of the body. - Several [recent Italian studies](https://www.ncbi.nlm.nih.gov/pubmed/29990992) found that it favorably modulates mitochondrial respiratory pathways. - *[T2] may actively regulate energy metabolism at the cellular, rather than the nuclear, level*, according to [a paper published](https://www.ncbi.nlm.nih.gov/pubmed/28192176) in *Molecular and cellular endocrinology*. Like the classic Mitochondrial Nootropic Creatine, T2 will give you an edge in the gym and your athletic performance. ##  **Cancer** Preventative ![cancer cell culture bio](https://www.limitlessmindset.com/images/cancer-cell-culture-bio-600.webp) Cancer is often caused by oxidative stress; free radicals disrupt the normal replication of genes and cells, which results in cancer. A [2019 Italian study](https://www.ncbi.nlm.nih.gov/pubmed/31024454) found that T2 protected from mtDNA oxidative damage. If you have a family history of cancer, you should be concerned with prevention. From a [2017 paper](https://www.ncbi.nlm.nih.gov/pubmed/28362337): > The inhibitory action on DNL exerted by T2 makes this compound a potential and attractive drug for the treatment of some metabolic diseases and cancer. If you have a family history of cancer, check out my deep-dive piece, [The Cancer Prevention Protocol](https://www.limitlessmindset.com/blog/479-cancer-prevention). ##  Promotes Healthy **Libido** ![men women sex libido 750](https://www.limitlessmindset.com/images/stories/blog/men_women_sex_libido_750.jpg) Anecdotally, T2 makes you a *Corvette in the bedroom* as well. Its mitochondria-empowering effect will enhance sex hormones (for him and her). ##  **Risk Grade**: C Throughout the scientific literature, it’s emphasized that T2 has not been rigorously studied in humans. The animal studies have not identified any concerning side effects, but T2 isn’t in the same risk category as more common supplements like Vitamin C or Nutraceuticals. The [*Endocrinology* article](https://www.limitlessmindset.com/#Endocrinology) emphasized that it’s somewhat risky as a supplement. > it is not evident from the published studies what conditions allow for its safe and effective use in humans. It urges... > more comprehensive studies in humans and animal models are clearly needed to fully evaluate any potential risks. And it’s advised not to *stack* T2 with a bunch of other workout supplements, according to the article doing so according to the article, *entails significant risk of untoward effects*. ##  **Sources** ![thyronine molecule](https://www.limitlessmindset.com/media/reviews/photos/original/65/81/20/thyronine-29-1712241750.webp) **Before taking a supplement like this, you should demand to see a COA/spectroscopy report verifying purity**. I found just one vendor, [Dr. Westin Childs](https://www.limitlessmindset.com/Thyronine-AMZ), of T2 supplements that measures up to the high standards I have when it comes to this sort of thing (check out their COAs [here](https://www.restartmed.com/third-party-test-results/)). They are based in the USA. If you're in the EU, Australia, or elsewhere - sorry - I couldn't find credible sources in your geographic neighborhood. I'd direct your attention to... #### ***Downloadable** Thyroid Support?* You may be interested in taking L-Thyroxine (similar to Thyronine) as an [*infoceutical*](https://www.infopathy.com/en/infoceuticals/l-thyroxine?invite=18735093) - a non-pharmacological, side-effect-free version of the drug that takes advantage of the phenomenon of *water memory* - which is imprinted on water via quantum collocation and electromagnetism using this device... Infocueticals typically have 1/3 or half the effect of the actual medicine being imprinted. If you're skeptical of Infopathy, that's understandable; it's a game-changing application of a little-known scientific phenomenon. But I'd urge you to evaluate the scientific evidence (presented in my biohacker review) that *downloadable medicine is no longer science fiction...* ##  **Better Thyroid Support Options** Given the fact that it's hard to find and entails some risks if it's Thyroid support that you're after, I think there are some better options out there. Notably, the Nootropic [L-Tyrosine](https://www.limitlessmindset.com/nootropic-ingredients/323-l-tyrosine), the adaptogens which help broadly with stress management, [Methylene Blue](https://www.limitlessmindset.com/nootropic-ingredients/286-methylene-blue), and Iodine from a natural source like [Irish Sea Moss](https://www.limitlessmindset.com/Sea-Moss) --- While you're waiting on your next supplement order, vibe out to this industrial EDM **song about thyroid support**... ### Nootropic Ingredients [Subscribe to the Limitless Podcast](https://www.limitlessmindset.com/LM-Podcast) To Listen on the Go ### Photos [![Thyronine](https://www.limitlessmindset.com/data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)](https://www.limitlessmindset.com/media/reviews/photos/original/78/09/6e/thyronine-85-1587410130.webp "Thyronine") [![Thyronine molecule](https://www.limitlessmindset.com/data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)](https://www.limitlessmindset.com/media/reviews/photos/original/65/81/20/thyronine-29-1712241750.webp "Thyronine molecule") ### Videos [![Thyronine "T2" - Top 9 Benefits of this Thyroid Biohack](https://www.limitlessmindset.com/data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)](https://www.limitlessmindset.com/listing-media/videos?m=dcB2B) {{title}} {{#ratings}} {{#editor}}   ({{count}}) {{/editor}} {{#user}}   ({{count}}) {{/user}} {{/ratings}} {{title}} {{#ownerCreatedBlock}} - {{#url}} {{#avatarSrc}} {{/avatarSrc}} {{^avatarSrc}} {{& avatar}} {{/avatarSrc}} {{name}} {{/url}} {{^url}} {{#avatar}} {{& avatar}} {{/avatar}} {{name}} {{/url}} - {{/owner}} {{#created}} - {{created}} {{/ownerCreatedBlock}} {{#category}} Category: {{category.title}} {{/category}} {{#fields}} {{#showLabel}} {{label}}: {{/showLabel}} {{& text}} {{/fields}} -