---
title: Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. - Limitless Mindset
description: A series of amides and sulfonamides, structurally related to DM235 (sunifiram) and MN19 (sapunifiram),
author: Jonathan Roseland
url: https://www.limitlessmindset.com/scientific-studies/1003-design,-synthesis-and-nootropic-activity-of-new-analogues-of-sunifiram-and-sapunifiram,-two-potent-cognition-enhancers
---

# Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.

[![Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.](https://www.limitlessmindset.com/data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)](https://www.limitlessmindset.com/media/reviews/photos/original/1d/bb/8f/design,-synthesis-and-nootropic-activity-of-new-analogues-of-sunifiram-and-sapunifiram,-two-potent-cognition-enhancers-34-1411845152.webp "Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.")

**Abstract**
A series of amides and sulfonamides, structurally related to DM235 (sunifiram) and MN19 (sapunifiram), derived by ring expansion or contraction, or by inversion of the exocyclic amide function, have been synthesized and tested for cognition-enhancing activity in the mouse passive-avoidance test. Some of the compounds display good antiamnesic and procognitive activity, with higher potency than piracetam, and with a potency similar to the parent compounds.

### Scientific Studies & Papers

Author of Study or Paper

Martini E, Salvicchi A, Ghelardini C, Manetti D, Dei S, Guandalini L, Martelli C, Melchiorre M, Cellai C, Scapecchi S, Teodori E, Romanelli MN.

Source

Department of Pharmaceutical Sciences, Laboratory of Design, Synthesis and Study of Biologically Active Heterocycles (HeteroBioLab), University of Florence

Date Published

2009 in Bioorganic & medicinal chemistry.

Scientific Link

http://www.ncbi.nlm.nih.gov/pubmed/19786353

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