---
title: Inhibitory effect of icariin on acetylcholinesterase - Limitless Mindset
description: "Acetylcholinesterase (AChE) inhibitors are mainly used in the treatment of Alzheimer's disease (AD)."
author: Jonathan Roseland
url: https://www.limitlessmindset.com/scientific-studies/1019-inhibitory-effect-of-icariin-on-acetylcholinesterase
---

# Inhibitory effect of icariin on acetylcholinesterase

[![Inhibitory effect of icariin on acetylcholinesterase](https://www.limitlessmindset.com/data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)](https://www.limitlessmindset.com/media/reviews/photos/original/12/02/90/inhibitory-effect-of-icariin-on-acetylcholinesterase-91-1413240454.webp "Inhibitory effect of icariin on acetylcholinesterase")

**Abstract**
Acetylcholinesterase (AChE) inhibitors are mainly used in the treatment of Alzheimer's disease (AD). The inhibitory effect of icariin on the activity of AChE was investigated by inhibition kinetics. The binding interaction and binding sites between icariin and AChE were also studied by using fluorimetry and molecular docking, respectively. The results showed that icariin could potently inhibit the activity of AChE, the IC50 value was determined to be 3.50 x 10(-8) mol x L(-1), and the determined IC50 value to tacrine was 0.75 x 10(-8) mol x L(-1). Kinetic analyses showed that icariin is a reversible and mixed type AChE inhibitor. The inhibition constants K1 and K(IS) were determined to be 2.67 x 10(-8) and 4.43 x 10(-8) mol x L(-1), respectively. Icariin binds selectively to the AChE peripheral anionic site via hydrogen bonds and Van der Waals forces.

### Scientific Studies & Papers

Author of Study or Paper

Zhang YD, Cai YN, Zhang Q, Qi ZL, Gao QQ

Source

Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province

Date Published

2012 in Yao xue xue bao = Acta pharmaceutica Sinica.

Scientific Link

http://www.ncbi.nlm.nih.gov/pubmed/23227542

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