---
title: Ladasten versus placebo effect self-evaluated by neurasthenia patients with different EEG alpha rhythm types - Limitless Mindset
description: The study was focused on the clinico-pharmacological analysis of differences between subjective and objective assessment of the effects of antiasthenic drug ladasten and placebo effects in patients with neurasthenia with different individual patterns manifested in their EEG alpha rhythms
author: Jonathan Roseland
url: https://www.limitlessmindset.com/scientific-studies/1463-ladasten-versus-placebo-effect-self-evaluated-by-neurasthenia-patients-with-different-eeg-alpha-rhythm-types
---

# Ladasten versus placebo effect self-evaluated by neurasthenia patients with different EEG alpha rhythm types

[![Ladasten versus placebo effect self-evaluated by neurasthenia patients with different EEG alpha rhythm types](https://www.limitlessmindset.com/data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)](https://www.limitlessmindset.com/media/reviews/photos/original/e9/56/aa/ladasten-versus-placebo-effect-self-evaluated-by-neurasthenia-patients-with-different-eeg-alpha-rhythm-types-98-1506535527.webp "Ladasten versus placebo effect self-evaluated by neurasthenia patients with different EEG alpha rhythm types")

**Abstract**
The study was focused on the clinico-pharmacological analysis of differences between subjective and objective assessment of the effects of antiasthenic drug ladasten and placebo effects in patients with neurasthenia with different individual patterns manifested in their EEG alpha rhythms and MMPI findings. It is established that, in patients with neurasthenia characterized by reduced EEG alpha activity combined with emotional lability and inertness, the therapeutic action and effectiveness of ladasten and placebo was more robust (the subjective estimation was higher) than in patients with prominent alpha rhythm and sthenic personal traits. The self-assessment of the effect of single test doses of ladasten and placebo was independent of the individual differences of EEG alpha rhythm organization and personal traits with respect to tolerability, wish to continue the treatment, activating and calming effects. In long-term treatment, higher subjective estimations of the ladasten and placebo effect appeared in patients with reduced EEG alpha rhythm, and the difference corresponded to objective indices of the psychotropic action and effectiveness of the drug.

### Scientific Studies & Papers

Author of Study or Paper

Neznamov GG, Bochkarev VK, Reutova MA, Shabanova AA, Siuniakov SA.

Date Published

2012

About Study

- Placebo Controlled
- Human Study
- Clinical Trials

Scientific Link

https://www.ncbi.nlm.nih.gov/pubmed/22834121

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