---
title: Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthood. - Limitless Mindset
description: Existing evidence links greater dietary intake of fish and (n-3) PUFA to better early brain development and lowered risk of cognitive disorders in late life. The mechanisms for these associations remain unclear and may be related to specific (n-3) fatty acids and may concern cognitive function generally rather than only early brain development and age-related cognitive dysfunction. In this investigation, we tested potential associations between (n-3) fatty acids in serum phospholipids and major dimensions ...
author: Jonathan Roseland
url: https://www.limitlessmindset.com/scientific-studies/507-docosahexaenonic-acid-is-associated-with-cognitive-functioning
---

# Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthood.

[![Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthood.](https://www.limitlessmindset.com/data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)](https://www.limitlessmindset.com/media/reviews/photos/original/96/a5/0a/_universitypitsburg-1361991202.webp "Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthood.")

Existing evidence links greater dietary intake of fish and (n-3) PUFA to better early brain development and lowered risk of cognitive disorders in late life. The mechanisms for these associations remain unclear and may be related to specific (n-3) fatty acids and may concern cognitive function generally rather than only early brain development and age-related cognitive dysfunction. In this investigation, we tested potential associations between (n-3) fatty acids in serum phospholipids and major dimensions of cognitive functioning in mid-life adults. Participants were 280 community volunteers between 35 and 54 y of age, free of major neuropsychiatric disorders, and not taking fish oil supplements. Dietary biomarkers were alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenonic acid (DHA) in serum phospholipids measured using GC. Five major dimensions of cognitive functioning were assessed with a 75-min battery of neuropsychological tests. In covariate adjusted regression models, higher DHA (mol %) was related to better performance on tests of nonverbal reasoning and mental flexibility, working memory, and vocabulary (P

### Scientific Studies & Papers

Author of Study or Paper

Muldoon MF, Ryan CM, Sheu L, Yao JK, Conklin SM, Manuck SB.

Source

Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 15260, USA. This email address is being protected from spambots. You need JavaScript enabled to view it.

Date Published

2010

Scientific Link

[http://www.ncbi.nlm.nih.gov/pubmed/20181791](http://www.ncbi.nlm.nih.gov/pubmed/20181791)

{{title}}

{{#ratings}}

{{#editor}}

 

({{count}})

{{/editor}}

 {{#user}}

 

({{count}})

{{/user}}

{{/ratings}}

{{title}}

{{#ownerCreatedBlock}}

- {{#url}} {{#avatarSrc}} {{/avatarSrc}} {{^avatarSrc}} {{& avatar}} {{/avatarSrc}} {{name}} {{/url}} {{^url}} {{#avatar}} {{& avatar}} {{/avatar}} {{name}} {{/url}}
- {{/owner}} {{#created}}
- {{created}}

{{/ownerCreatedBlock}}

 {{#category}}

Category: {{category.title}}

{{/category}}

{{#fields}}

{{#showLabel}}

{{label}}:

{{/showLabel}}

{{& text}}

{{/fields}}