---
title: Differences and similarity in the interaction of fenibut, baclofen and diazepam with phenylethylamine - Limitless Mindset
description: The derivatives of GABA and beta-phenylethylamine the tranquilizer phenibut and muscle relaxant baclofen diminished all studied effect of PEA in mice, namely seizures, sedation, excitation, hyperthermia.
author: Jonathan Roseland
url: https://www.limitlessmindset.com/scientific-studies/867-fenibut-baclofen-diazepam-phenylethylamine
---

# Differences and similarity in the interaction of fenibut, baclofen and diazepam with phenylethylamine

[![Differences and similarity in the interaction of fenibut, baclofen and diazepam with phenylethylamine](https://www.limitlessmindset.com/data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)](https://www.limitlessmindset.com/media/reviews/photos/original/a9/40/1f/differences-and-similarity-in-the-interaction-of-fenibut,-baclofen-and-diazepam-with-phenylethylamine-77-1394565004.webp "Differences and similarity in the interaction of fenibut, baclofen and diazepam with phenylethylamine")

Abstract
The derivatives of GABA and beta-phenylethylamine (PEA) the tranquilizer phenibut and muscle relaxant baclofen (p-chloro-beta-phenyl-GABA, lioresal) diminished all studied effect of PEA in mice, namely seizures, sedation, excitation, hyperthermia. Diazepam diminished only seizures whereas haloperidol excitation and hyperthermia. PEA injections anatogonized (the sedative and hypothermic effects of phenibut and diazepam and the anticonvulsant (against l-kynurenine) effect of phenibut and baclofen. The role of antagonism to PEA in the mechanism of the antianxiety effect of tranquilizers is discussed.

### Scientific Studies & Papers

Author of Study or Paper

Lapin IP.

Source

Farmakologiia i toksikologiia.

Scientific Link

[http://www.ncbi.nlm.nih.gov/pubmed/4043364](http://www.ncbi.nlm.nih.gov/pubmed/4043364)

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