---
title: Chronic treatment with sulbutiamine improves memory in an object recognition task - Limitless Mindset
description: The effect of a sulbutiamine chronic treatment on memory was studied in rats with a spatial delayed-non-match-to-sample (DNMTS) task in a radial maze and a two trial object recognition task.
author: Jonathan Roseland
url: https://www.limitlessmindset.com/scientific-studies/883-chronic-treatment-with-sulbutiamine-improves-memory-in-an-object-recognition-task
---

# Chronic treatment with sulbutiamine improves memory in an object recognition task

[![Chronic treatment with sulbutiamine improves memory in an object recognition task](https://www.limitlessmindset.com/data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)](https://www.limitlessmindset.com/media/reviews/photos/original/6f/2a/89/chronic-treatment-with-sulbutiamine-improves-memory-in-an-object-recognition-task-90-1400188439.webp "Chronic treatment with sulbutiamine improves memory in an object recognition task")

Abstract
The effect of a sulbutiamine chronic treatment on memory was studied in rats with a spatial delayed-non-match-to-sample (DNMTS) task in a radial maze and a two trial object recognition task. After completion of training in the DNMTS task, animals were subjected for 9 weeks to daily injections of either saline or sulbutiamine (12.5 or 25 mg/kg). Sulbutiamine did not modify memory in the DNMTS task but improved it in the object recognition task. Dizocilpine, impaired both acquisition and retention of the DNMTS task in the saline-treated group, but not in the two sulbutiamine-treated groups, suggesting that sulbutiamine may counteract the amnesia induced by a blockade of the N-methyl-D-aspartate glutamate receptors. Taken together, these results are in favor of a beneficial effect of sulbutiamine on working and episodic memory.

### Scientific Studies & Papers

Author of Study or Paper

Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H.

Source

Key-Obs S.A., Centre d'Innovation, 16 rue Léonard de Vinci, 45074 Orléans Cedex 2, France. This email address is being protected from spambots. You need JavaScript enabled to view it.

Date Published

2005 in Progress in neuro-psychopharmacology & biological psychiatry.

Scientific Link

[http://www.ncbi.nlm.nih.gov/pubmed/15951087](http://www.ncbi.nlm.nih.gov/pubmed/15951087)

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