---
title: Psychoimmunomodulatory effect of phenotropil in animals with immune stress - Limitless Mindset
description: We studied the effect of phenotropil (25 mg/kg intraperitoneally, 5 days) on the immune and psychoemotional state of Wistar rats with LPS-induced immune stress. Hyperactivity of the immune system in animals after treatment with Pseudomonas aeruginosa LPS (100 μg/kg intraperitoneally, 3 days) manifested in a significant increase in the delayed-type hypersensitivity index, antibody titer in the reaction of passive hemagglutination, and phagocytic activity of peripheral blood neutrophils. Locomotor, ...
author: Jonathan Roseland
url: https://www.limitlessmindset.com/scientific-studies/911-psychoimmunomodulatory-effect-of-phenotropil-in-animals-with-immune-stress
---

# Psychoimmunomodulatory effect of phenotropil in animals with immune stress

[![Psychoimmunomodulatory effect of phenotropil in animals with immune stress](https://www.limitlessmindset.com/data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)](https://www.limitlessmindset.com/media/reviews/photos/original/9b/43/0d/psychoimmunomodulatory-effect-of-phenotropil-in-animals-with-immune-stress-46-1403568367.webp "Psychoimmunomodulatory effect of phenotropil in animals with immune stress")

We studied the effect of phenotropil (25 mg/kg intraperitoneally, 5 days) on the immune and psychoemotional state of Wistar rats with LPS-induced immune stress. Hyperactivity of the immune system in animals after treatment with Pseudomonas aeruginosa LPS (100 μg/kg intraperitoneally, 3 days) manifested in a significant increase in the delayed-type hypersensitivity index, antibody titer in the reaction of passive hemagglutination, and phagocytic activity of peripheral blood neutrophils. Locomotor, orientation, and exploratory activities were reduced, while anxiety increased in animals with immune stress. Phenotropil exhibited the psychoimmunomodulatory effect under these conditions, which manifested in prevention of anxiety and fear response, increase in horizontal locomotion and exploratory behavior, and improvement of immunoreactivity.

### Scientific Studies & Papers

Author of Study or Paper

Savchenko AIu, Zakharova NS, Stepanov IN.

Date Published

2011 in Bulletin of experimental biology and medicine.

Scientific Link

http://www.ncbi.nlm.nih.gov/pubmed/22442801

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