Coluracetam [Biohacker Review]

Coluracetam Powder

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Coluracetam by Swiss Chems
By Jonathan Roseland

I'm not a doctor, medical professional, or trained therapist. I'm a researcher and pragmatic biohacking practitioner exercising free speech to share evidence as I find it. I make no claims. Please practice skepticism and rational critical thinkingYou should consult a professional about any serious decisions that you might make about your health. Affiliate links in this article support Limitless Mindset - spend over $150 and you'll be eligible to join the Limitless Mindset Secret Society.

Biohacker ReviewThe caviar of antidepressants to vanquish seasonal affective disorder

I filmed my video about this drug in front of the Parliament Building in Bucharest, Romania. As you can see it's a very gray, brooding building, in a part of the world that this time of the year is also very gray and brooding during winter.

Bucharest, Romania

For the past four months or so I've been living in Eastern Europe, which is a nicer part of the world than you would guess from the headlines but during this season it's kind of a global hotspot for SAD (seasonal affective disorder) which  -  unless you live somewhere you need to worry about coconuts falling on your head  -  is something you've probably experienced. During the winter season, there's a whole lot less sunlight, the days are shorter, you spend more time indoors, you sleep more, you might gain some weight, you're less likely to go to the gym, or hang out with friends, and a lot of people suffer from mild depression as a result for a couple of months out of the year.

So there are some holistic ways to beat SAD, like setting up a home gym, following a strict diet, or even installing special lights in your bedroom that signal to your neurobiology that it's summertime. However, I'm a digital nomad and none of these options work great for me. For me, Coluracetam has been an irreplaceable Biohack for beating SAD

It's not a hardcore focus drug like Modafinil, nor does it give me a bunch of energy and pep like caffeine or Piracetam. What it does is just add a subtle and underlying positivity to my mood. There's a noticeable difference on it and off it, especially in this dreadfully gloomy part of the world.

It's a quintessential antidepressant

Some comedian made a joke about what happens if you take antidepressants when you aren't actually depressed… Do you just become more awesome? In the case of Coluracetam, not so much, I would say it improves my mood by 25% - 75%.

One day I did about 20 milligrams 15 minutes before my afternoon meditation session, during the meditation I can appreciate the optimistic mood it puts me into. This sensation lasted about four hours.

It's not great for mood permeability, I did it a few times near the end of my workday when I was in zombie borg drone mode and headed to do something social. It does make me slightly more optimistic which is helpful but it didn't help me get in a carefree social mood like Phenibut, Kratom, or even meditation does. It won't be my go-to social smart drug

Nootropics can be enablers of Nihilism

While one day I started watching documentaries about ISIS and the European migrant crisis, and I was drawn into the rabbit hole of Nihilism.
The healthy thing to do would be to not watch the depressing content, but I found myself using the antidepressant as an excuse to indulge my Nihilism.


I tried Coluracetam for the first time in the amount of about 20 milligrams when I was doing a walking tour of Berlin (got a few touristy photos attached). Despite walking around an amazing city center on a beautiful summer day I didn't quite experience this often-praised effect of the outdoor world seeming more vivid.


A Youtube commenter suggested stacking Coluracetam with L-Theanine, which I tried and it's a pretty good stack, especially in combination with some delicious Bulletproof-style coffee. The creative mindset that L-Theanine puts me in is nicely complemented by the optimism that Coluracetam stimulates - this has become my go-to stack since I ran out of Piracetam.
Speaking of coffee, anecdotally Coluracetam has this cool effect of reversing caffeine tolerance. I, unfortunately, did not experience this, at least not noticeably. Another consistent way to reverse caffeine tolerance is just to stop consuming caffeine for about 10 days and your caffeine tolerance will almost completely go away. And after consuming just a single cup of coffee you will again feel like a Greek god consuming ambrosia in the fields of Elysium. Coluracetam did not have the same effect for me.

Coluracetam Powdered

It has a rocky, clumpy consistency that reminds me of cocaine  -  the tiny rocks feel like boulders under my tongue. You may need to break it up before consumption. I've been taking it sublingually because it's so damn expensive that I don't want to waste a single granule of it. Its taste is not pleasant and it kind of lingers on your palette, I don't recommend taking it before a meal. It doesn't taste great but it's not as bad as some drugs I've tried.

Scienceguy on Longecity suggested it potentiates Oxiracetam, I've taken it now a couple of times with Caballo which has Oxiracetam but I'm not sure if I've experienced this yet…
One day I was operating on about four hours of sleep, so I was somewhat sleep-deprived and kept slipping back into an unfocused funk. I took Coluracetam around 1 PM and 4 PM and there was a disappointing absence of an effect.

I wish I could rate Coluracetam higher, but I'm deducting two stars because it's just not a great value, there are plenty of Nootropics that gram for gram, cost a 3rd or 4th of Coluracetam and have just as helpful effect on mood, focus, and memory. For mere economics, I wouldn't reorder it.

3 stars

This Japanese-developed Racetam is one of the latest nootropics to be inspired by Piracetam.

  • Strong Cholinergic Nootropic
  • Increases Memory & Focus
  • Enhances High-Affinity Choline Uptake

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Supplement or Drug

  • Certificate of Analysis by 3rd Party Lab
  • Cryptocurrency Accepted
  • Pharmaceutical Grade
Type of Consumable
Pill or Capsule
Nootropic Ingredients


Coluracetam molecule
Me, touring Berlin on Coluracetam
Coluracetam Powder
Coluracetam Powder
Freezing my balls off in Bucharest, Romania


A quintessential mood-stabilizing antidepressant ⭐⭐⭐ Biohacker Review of Coluracetam

Editor review

1 review
The Caviar of Antidepressants to Vanquish Depression
(Updated: February 18, 2019)
Overall rating
Good value
Makes you feel 'Limitless' - Improves memory
Ability to focus
Energy and productivity
Wakefulness and alertness
Social Confidence
Verbal ability
Me, touring Berlin on Coluracetam
Coluracetam Powder
Freezing my balls off in Bucharest, Romania
A quintessential mood-stabilizing antidepressant ⭐⭐⭐ Biohacker Review of Coluracetam
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