---
title: Antidepressant-like effects of aniracetam in aged rats and its mode of action. - Limitless Mindset
description: Aniracetam has been reported to be efficacious for treating poststroke depression, but no studies that basically examined the antidepressive effects have been made.
author: Jonathan Roseland
url: https://www.limitlessmindset.com/scientific-studies/836-antidepressant-like-effects-of-aniracetam-in-aged-rats-and-its-mode-of-action
---

# Antidepressant-like effects of aniracetam in aged rats and its mode of action.

[![Antidepressant-like effects of aniracetam in aged rats and its mode of action.](https://www.limitlessmindset.com/data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)](https://www.limitlessmindset.com/media/reviews/photos/original/7b/b8/5c/antidepressant-like-effects-of-aniracetam-in-aged-rats-and-its-mode-of-action-67-1390874185.webp "Antidepressant-like effects of aniracetam in aged rats and its mode of action.")

**Abstract**
RATIONALE:
Aniracetam has been reported to be efficacious for treating poststroke depression, but no studies that basically examined the antidepressive effects have been made.
OBJECTIVE:
We aimed to test the antidepressant-like property of aniracetam in rats and to clarify the mechanisms of action through the interaction studies with some receptor antagonists.

CONCLUSIONS:
These results indicate that aniracetam acts more effective when the forced swim stress-induced immobility is accompanied with brain dysfunction that occurs with aging. The antidepressant-like activity of aniracetam, which is probably due to the combined effects of 2-pyrrolidinone and N-anisoyl-GABA, may be mediated by mainly facilitating dopaminergic transmission (dopamine release and dopamine D2 receptor activation) through nicotinic acetylcholine receptor stimulation.

# Other Racetams

[Cost of Racetams by Dosage](https://infogr.am/cost-of-racetams-by-dosage) | [Create Infographics](https://infogr.am)

# Other Racetams

### Scientific Studies & Papers

Author of Study or Paper

Nakamura K, Tanaka Y.

Date Published

CNS Supporting Laboratory, Nippon Roche Research Center, 200 Kajiwara, Kamakura, Kanagawa, Japan

Scientific Link

[http://www.ncbi.nlm.nih.gov/pubmed/11702095](http://www.ncbi.nlm.nih.gov/pubmed/11702095)

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