Cannabidiols (CBD)

Cannabidiols (CBD)

Cannabidiols (CBD)
By Jonathan Roseland

I'm not a doctor, medical professional, or trained therapist. I'm a researcher and pragmatic biohacking practitioner exercising free speech to share evidence as I find it. I make no claims. Please practice skepticism and rational critical thinkingYou should consult a professional about any serious decisions that you might make about your health. Affiliate links in this article support Limitless Mindset - spend over $150 and you'll be eligible to join the Limitless Mindset Secret Society.

CBD is the non-psychoactive component of Cannabis and a real multi-tool as a supplement

This article is mostly going to focus on decoding what the human studies are saying about CBD and how this squares up with the anecdotal experiences of Biohackers online. For more of my own personal experiences, thoughts, and comparisons please see the written and video reviews in the sidebar.

A mitochondria hack

Mitochondria and the Future of MedicineFrom Dr. Lee Know's recent book...

In 2012, French scientists discovered that mitochondria contained cannabinoid receptors on their membranes. This revelation laid the groundwork for successive investigations into the role of the ECS in regulating mitochondrial activity. Since the ability to conduct research into this incredible plant has become easier , scientific evidence is showing that cannabidiol ( CBD ) and tetrahydrocannabinol ( THC ) — the two main phytocannabinoids from the cannabis plant — can directly and indirectly impact the mitochondria . It turns out that many of the biological processes that involve mitochondria are modulated by endo - and phytocannabinoids. On the surface, research on cannabinoids often shows contradictory results. Cannabinoids are notorious for exerting opposite effects under different situations. CBD and THC have been shown to balance physiological excesses as well as deficiencies. A small dose of cannabis stimulates while a large dose tends to sedate. Phytocannabinoids can destroy cancer cells but leave healthy cells alone. (2927-2934)

Sleep enhancer

CBD, a recent French paper evaluated CBD as an Ergogenic holistic sports performance enhancer, it emphasizes its beneficial effect on sleep

Preclinical studies suggest that CBD could be useful to athletes due to its anti-inflammatory, analgesic, anxiolytic, neuroprotective properties and its influence on the sleep-wake cycle.

Before bed...

Take an anxiolytic pre-bedtime cocktail. I like tea, here’s what I mix to make a hearty sleepytime tea: Ashwagandha (powdered), Chamomile, raw honey, and organic apple cider vinegar. To take my sleep quality to the next level, on top of this I’ll take several hundred milligrams of magnesium and a CBD supplement.

Want to take this to the next level? Stack some other sleep-enhancing supplements before bed: C60, Magnesium, Ashwagandha

Vs depression

If you want something to relax you at the end of the day — there are a lot better options out there than smoking weed; herbal adaptogens, meditation, yoga, and even CBD oil which can help with depression and is not intoxicating or habit-forming.

For relentless recovery

It has huge value to athletes in its effect of stimulating powerful restorative sleep. What science says about CBD and healing...

  • There are no human studies specifically evaluating CBD and workout injuries but two English studies. One which established its benefit in treating neurogenic symptoms - recovery from nervous system disorders, damage, and dysfunction. The other showed relief of central neuropathic pain resulting from injury to the nerves which relay signals from the spinal cord to the shoulder, arm, and hands.
  • A 2020 clinical trial of 26 healthy men evaluated the effects of CBD on Hemodynamics, the dynamics of blood flow. It resulted in a reduction in arterial stiffness and improvements in endothelial function, which enhanced isometric exercise performance.
  • A 2015 study demonstrated that CBD leads to improvement in fracture healing, via its the critical mechanical role of collagen crosslinking enzymes.

  Sources

Purity is a concern with CBD supplements

A 2019 study published by the German Sports University in Cologne warns that more than 30% of the full spectrum CBD products sold in Germany contained psychoactive THC, which will show up in a drug test and potentially disqualify athletes, which is NOT disclosed on the label or mentioned in the products’ marketing. I don’t think this is because the manufacturers are trying to trick their customers into getting high, the THC content is likely a result of shoddy CBD extraction and quality assurance.

Downloadable CBD?

You may be interested in taking it as an infoceutical - a non-pharmacological, side-effect-free version of the supplement that takes advantage of the phenomenon of water memory - which is imprinted on water via quantum collocation and electromagnetism using this device...

Infocueticals typically have 1/3 or half the effect of the actual medicine being imprinted. If you're skeptical of Infopathy that's understandable, it's a game-changing application of a little-known scientific phenomenon. But I'd urge you to evaluate the scientific evidence (presented in my biohacker review) that downloadable medicine is no longer science fiction...

Cofactors

Turmeric and CBD are a bioavailability dream team...

Turmeric plays a significant role here because the isolated curcuminoids (which are the active ingredients of a high-curcumin-containing turmeric plant) mix with the cannabinoids and terpenoids of CBD, causing their bioavailability to explode. When you take CBD with curcumin or turmeric high in curcumin, you can get five to ten times the effects that you otherwise would. (p.467)

BPC-157 + CBD: The Recovery Dream Team

There are two powerful synergistic healing agents, that if you can afford them both, absolutely belong in your bodybuilding warchest.

BPC-157 is the Wolverine Drug for accelerated healing, but it’s not actually a drug (or a supplement) it’s a “research chemical” analogous to a peptide that is manufactured in our guts.

  • It has not yet undergone a “gold standard” double-blind, placebo-controlled human trial but it's far from being an unpredictable, unproven research chemical. It is very popular worldwide in the bodybuilding scene, it has been thoroughly evaluated by many thousands of “lab rats” in gyms around the world and has earned a reputation as a safe and fast-acting healing agent.
  • It’s been evaluated for decades in animal studies that have uncovered its wide range of effects and benefits, there are over 120 scientific papers published about it.
  • Anecdotally, it’s reported that it enhances sleep profundity significantly.

More about BPC-157 here...

CBD and HRV

I’ve reached some very sublime flowstates with cannabis (you probably don’t want to get high on weed in the middle of the workday, so maybe try some small doses of CBD oil) and HRV training, as have others and the Heartmath Institute’s website has some interesting published research on HRV and flow.

Dosing some CBD is a great idea if you watch creepy movies in the evening...

If you do find yourself accompanying a group of friends to the latest Halloween blockbuster, consider following it up with a dose of GABA-supporting compounds, such as passionflower extract, lemon extract, cannabidiol (CBD), or a phenibut supplement. (p.36)

LSD Overdose?

Interestingly, I have found that if you take slightly too much LSD, a small dose of CBD (between 10 and 20 mg) seems to take the edge off. (p.184)

Usage and Dosage

Boundless bookBen Greenfield, obsessive Biohacker, gives some tips in his book...

I recommend starting on the lower dosing end and slowly increasing the dose to find your optimal microdose. I have personally found 10 to 20 mg of CBD to help manage anxiety and stress and boost focus. Higher doses of between 30 and 40 mg can help you fall asleep more easily. In fact, I have taken doses as high as 100 mg before bed, slept like a baby, and woken up with no grogginess. CBD tolerances vary from individual to individual, and if you take it and notice nothing, I recommend you try more. (p.159)

Photos

Cannabidiols (CBD)

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