Cortexin by RUPHARMA

Cortexin® is a mixture of neuropeptide fractions, amino acids, vitamins, and minerals. It has a pronounced but subtle positive effect on the brain.

Similar to Cerebrolysin, Cortexin is based on neuropeptides and amino acids. the pharmacological difference is that Cortexin has significantly more peptide fractions and fewer amino acids. Another notable difference is that it doesn't come from pig brains, so it may be a better option for people who really want to inject their Nootropics but just don't like pigs.

Anti-Aging Effects

Cortexin® has the following effects:

• Nootropic effect: Improves higher cerebral functions, processes of learning and memory, concentration, attention, and tolerance to mental and physical stress.
• Neuroprotective effect: protects neurons against different endogenous neurotoxic factors (glutamate, calcium ions, and free radicals) and reduces the toxic impact of psychotropic agents.
• Antioxidant effect: inhibits lipid peroxidation, increases the survival of neurons under oxidative stress and hypoxia.
• Tissue-specific effect: activates the metabolism of neurons of the central and peripheral nervous system as well as reparative processes; also, promotes stimulation of cortical function and general improvement of the nervous system.

Research

It's an efficacious supplement that has been proven to be effective and safe on all possible levels: clinical, biological, cellular, genetic, and molecular. On Pubmed, you can find 19 clinical trials that evaluated Cortexin in humans.

• In the most recent study of 64 patients with epilepsy, it significantly decreased the frequency of seizures.
• A Russian double-blind placebo-controlled 2014 trial evaluated the Neuroprotective effects of low doses for ischemic stroke patients. It concluded: High efficacy and safety of cortexin in the complex treatment of patients with II has been shown. The best therapeutic effect was seen in group 1 (two 10-day courses of cortexin).
• It benefits those with open-angle glaucoma.
• One study evaluated it in combination with microcurrent reflexotherapy to treat cerebral palsy in young children.
• Another study found that it improved memory disorders in 86% of children aged 7-12 years.
• It had a positive effect on the symptoms of alcohol encephalopathy and alcohol polyneuropathy.
• Interestingly, a study done in Japan compared it with Vinpotropil and Noopept, called it an adaptogen, and noted how it modulated recovery of the physical and psychological efficiency under rapidly changing environment conditions.

Mechanism of Action

Is attributed to the following effects:

• Activation of neuronal peptides and neurotrophic cerebral factors;
• Optimization of the metabolic balance of excitatory and inhibitory amino acids as well as dopamine and serotonin;
• GABAergic actions: reduction of the paroxysmal convulsive activity of the brain, improvement of its bioelectrical activity, and prevention of free radicals formation (products of lipid peroxidation).

Country of Manufacture: Russia

Cofactors

Cortexin can be mixed with Cerebrolysin.

Usage

10-day cycles are recommended. Similar to Cerebrolysin you inject it intramuscularly, NOT intravenously, and definitely don't take it nasally like you do Semax. BACTERIOSTATIC WATER for the reconstitution of Cortexin can be bought on Amazon.

Side Effects

According to a study that evaluated it in 45 patients: The drug was well-tolerated, no side-effects were observed. However, a few Biohackers noted an undesirable side effect - persistent muscle fasciculations.

Risk?

I give this a C+ as a risk score. It's an injectable, it's been studied extensively in Russian but lacks international studies that have been peer-reviewed and published in English for the public in open journals. In my opinion, Cortexin is for those who need it to treat a serious illness or Biohackers with high-risk tolerance and demand for pharmacological novelty.

Cortexin has these amino acids, vitamins, and minerals.