Noopept by RUPharma

An economical psychostimulating Racetam from Russia with love.

Noopept is a nootropic supplement originally discovered and synthesized in Russia. It is officially promoted as a smart drug and cognitive enhancer. It is derived from the racetam family of drugs and shares similar mechanisms of action but is between 100 to 1000 times more potent than the prototypical smart drug, Piracetam but that's gram for gram, I'm not saying that it will make you 100X more Limitless than Piracetam. Its effect is quite similar to Piracetam actually but many find that it's a much better value.

Studies have shown Noopept to be neuroprotective and memory-enhancing in various tests. It is also said to be independently verified as the purest nootropic in Europe.

Nootropic Effects

Here's the deal with Noopept; it's a beloved Nootropic by Biohackers, by otherwise healthy, younger people seeking true performance enhancement, not treating or preventing degenerative diseases. There's a spectrum of responses to Noopept; about a third of Biohackers find it just mildly stimulating, a third are non-responders and don't notice anything, and about a third find it to be a quite brilliant smart drug that empowers the mind. You won't really know what it will do for you until you try it.

On-label indications:

• Increase memory, focus, and other cognitive abilities
• Anxiety and depression
• Asthenia/tiredness (lack of energy and motivation)
• Poor sleep

Neuroplasticity Hack

This supplement stimulates the expression of NGF and BDNF in rat hippocampus which is associated with the reduction and prevention of neuronal degeneration. The release of Brain-Derived Neurotrophic Factor (BDNF) helps keep our neurons healthy and alive, as well as strengthening the growth and differentiation of new neurons and synapses.

Origin

Importantly, the purity of the Russian genuine Noopept is 100%, unlike powders or capsules produced in other countries.

Research

The published research on Noopept is a bit scant compared to some of the other Racetams. Over 60 items of research about Noopept have been published. To summarize some of the notable study findings

• The most recent study found it to protect neurons in the hippocampus from glutamate toxicity.
• It enhances inhibitory synaptic transmission in the hippocampus.
• The research on NCBI proves that Noopept stimulates the expression of NGF and BDNF.

All the studies are Russian, in the future, I hope to see it evaluated by more labs and universities around the world.

Mechanism of Action

Unlike a peptide-derived compound, Noopept shows both high oral bioavailability and good blood-brain barrier penetration in humans.

Cofactors

One of the reasons that self-experimenters really like it is that it can be combined with a lot of other Nootropics for a synergistic effect.

• ACh precursors: Unless you get a lot of choline from your diet, it's a good idea to combine Noopept with something that supplements your acetylcholine; Alpha GPC, Choline Bitrate, etc
• Other racetams: There are some nice synergies of effect when taken in small doses alongside Piracetam or Oxiracetam.
  

Economics and Risk

As a Nootropic it's lower risk and it's relatively cheap. The Racetams are noted for their virtually nonexistent toxicity. So unlike some Biohacking options, there's no real downside and the upside is significant. I give it a Biohacker risk score of B+

• It's molecularly similar to and in the same category as the very well-tolerated Racetams.
• Thousands of savvy Biohackers have reported their experiences with it and there's a real lack of undesirable side effects.
• It doesn't deserve an A because there have only been three clinical trials rigorously evaluating Noopept in humans.

Usage and Dosage

With Noopept you don't need to wonder long if it's working for you. Typically its stimulating effect will become apparent within hours of dosing. Its effects on long-term memory can take up to 10-14 days of dosing to become noticeable. So try it for 2 weeks and you'll know if it's the smart drug for you.