Biohacker Review: NANOTROPIL NOVO® is next-level Phenylpiracetam

I got my hands on a package and have been using it on and off for a few weeks. I cycled off my daily-driver Nootropic, Nicotine, when I first went on it because wanted to more accurately gauge its effects. It's a quintessential cognitive enhancer...

• It enhanced my technical problem-solving capacities, which helped me get through a redesign and revamp of my website.
• It sharpened my memory and grasp of vocabulary a bit.
• I had words on the tip of my tongue less.
• Recently I've developed moderate Tinnitus (which probably has something to do with excessive news binging this crazy year) which caused some sleep deprivation. 200 milligrams helped some with sleep deprivation, but addressing the Tinnitus with meditation made a bigger difference.

Cortexin® is a mixture of neuropeptide fractions, amino acids, vitamins, and minerals. It has a pronounced but subtle positive effect on the brain.

Similar to Cerebrolysin, Cortexin is based on neuropeptides and amino acids. the pharmacological difference is that Cortexin has significantly more peptide fractions and fewer amino acids. Another notable difference is that it doesn't come from pig brains, so it may be a better option for people who really want to inject their Nootropics but just don't like pigs.

PINEALON Overview

Another Nootropic peptide that empowers the mind, although it’s better for treating brain disorders than it is for healthy people to use as a smart drug.

A Neuropeptide-Powered Nootropic

MEMOPROVE® is an innovative European Nootropic that, as its name implies, enhances memory and cognition. Whether you're a grad student, a hardworking professional, or just sick of forgetting where you left your keys - Neuropeptides can give you an edge. The active peptide in this Nootropic is N-PEP-12™.

Bromantane was developed in the 1970s at the Research Institute of Pharmacology in Russia, it was the first pharmaceutical of its kind that exhibited simultaneously both mild psychostimulating and anxiolytic effects.

LADASTEN (as it's referred to as a pharmaceutical) meets the profile of the kind of drug that Biohackers like to use as a smart drug; the polarity of psychostimulating and anxiolytic effects imbue an ideal mindset of relaxed arousal.

Mildronate modulates and improves the function of the heart which has a number of downstream performance-enhancing effects both for our physical and mental capacities.

Meldonium, or Mildronate, is prescribed to treat “different heart and vascular diseases,” according to the Latvian manufacturing company’s website, though it also notes that the drug can improve the “physical capacity” of healthy people. It increases blood flow, which improves exercise capacity in athletes.

Performance Enhancer

Off – label use of Meldonuim in healthy people: increasing exercise tolerance, learning, memory, and even sexual function. One athletic Biohacker reported enthusiastically

"I play ice hockey, tennis and I do weights training and yoga. I have personally taken Meldonium... before weights and yoga training... before ice hockey, and the benefits are immediate : more energy, no hunger, feeling light, as if my body was not heavy, also feeling really concentrate and aware and brain's functions seems enhanced. I could also add that this drug, make you not wanna lose, seems like it has a mental effect that keep you pushing more and refusing to lose or giving up and makes you wanna give your best until the end even in a losing game/match up."

Banned from the Olympics

Wada (World Anti-Doping Agency) found “evidence of it's use by athletes with the intention of enhancing performance” by virtue of carrying more oxygen to muscle tissue.

The decision to add Meldonium to the banned list was approved on September 16th, 2015, and it came into effect on January 1st, 2016. Wada had spent the previous year monitoring the drug before adding it to the banned list.

Meldonium gained popularity after Maria Sharapova, a famous tennis player, from Russia, said that she has been taking this drug for the last 10 years for health reasons. Also, a number of other world and Olympic champions admitted to taking it...

Eastern Exotics: Smart Drugs, Nootropics & Anti-Aging Agents from the Russosphere - Page 3 - Limitless Mindset

Semen Elistratov

{"id":1228,"form_id":93,"category":"category-1","name":"semen_elistratov.jpeg","path":"images\/bagallery\/original\/semen_elistratov.jpeg","url":"https:\/\/www.limitlessmindset.com\/images\/bagallery\/gallery-93\/compression\/semen_elistratov.jpeg","thumbnail_url":"\/images\/bagallery\/gallery-93\/thumbnail\/category-1\/semen_elistratov.jpeg","title":"Semen Elistratov","short":"","alt":"semen elistratov","description":"","link":"","video":"","settings":null,"likes":0,"imageId":"1","target":"blank","lightboxUrl":"semen-elistratov","watermark_name":"semen_elistratov.jpeg","hideInAll":0,"suffix":""}

Maria Sharapova

{"id":1229,"form_id":93,"category":"category-1","name":"maria-sharapova.jpeg","path":"images\/bagallery\/original\/maria-sharapova.jpeg","url":"https:\/\/www.limitlessmindset.com\/index.php?option=com_bagallery&task=gallery.compressionImage&id=1229","thumbnail_url":"\/images\/bagallery\/gallery-93\/thumbnail\/category-1\/maria-sharapova.jpeg","title":"Maria Sharapova","short":"","alt":"maria sharapova","description":"","link":"","video":"","settings":null,"likes":0,"imageId":"2","target":"blank","lightboxUrl":"maria-sharapova","watermark_name":"maria-sharapova.jpeg","hideInAll":0,"suffix":""}

Ekaterina Bobrova

{"id":1230,"form_id":93,"category":"category-1","name":"ekaterina-bobrova.jpeg","path":"images\/bagallery\/original\/ekaterina-bobrova.jpeg","url":"https:\/\/www.limitlessmindset.com\/images\/bagallery\/gallery-93\/compression\/ekaterina-bobrova.jpeg","thumbnail_url":"\/images\/bagallery\/gallery-93\/thumbnail\/category-1\/ekaterina-bobrova.jpeg","title":"Ekaterina Bobrova","short":"","alt":"ekaterina bobrova","description":"","link":"","video":"","settings":null,"likes":0,"imageId":"3","target":"blank","lightboxUrl":"ekaterina-bobrova","watermark_name":"ekaterina-bobrova.jpeg","hideInAll":0,"suffix":""}

Eduard Varganov

{"id":1231,"form_id":93,"category":"category-1","name":"eduard_varganov_copy1.jpeg","path":"images\/bagallery\/original\/eduard_varganov_copy1.jpeg","url":"https:\/\/www.limitlessmindset.com\/images\/bagallery\/gallery-93\/compression\/eduard_varganov_copy1.jpeg","thumbnail_url":"\/images\/bagallery\/gallery-93\/thumbnail\/category-1\/eduard_varganov_copy1.jpeg","title":"Eduard Varganov","short":"","alt":"eduard varganov copy1","description":"","link":"","video":"","settings":null,"likes":0,"imageId":"4","target":"blank","lightboxUrl":"eduard-varganov","watermark_name":"eduard_varganov_copy1.jpeg","hideInAll":0,"suffix":""}

Aleksey Lovchev

{"id":1232,"form_id":93,"category":"category-1","name":"aleksey_lovchev.jpeg","path":"images\/bagallery\/original\/aleksey_lovchev.jpeg","url":"https:\/\/www.limitlessmindset.com\/images\/bagallery\/gallery-93\/compression\/aleksey_lovchev.jpeg","thumbnail_url":"\/images\/bagallery\/gallery-93\/thumbnail\/category-1\/aleksey_lovchev.jpeg","title":"Aleksey Lovchev","short":"","alt":"aleksey lovchev","description":"","link":"","video":"","settings":null,"likes":0,"imageId":"5","target":"blank","lightboxUrl":"aleksey-lovchev","watermark_name":"aleksey_lovchev.jpeg","hideInAll":0,"suffix":""}

Abeba Aregawi

{"id":1233,"form_id":93,"category":"category-1","name":"abeba_aregawi.jpeg","path":"images\/bagallery\/original\/abeba_aregawi.jpeg","url":"https:\/\/www.limitlessmindset.com\/images\/bagallery\/gallery-93\/compression\/abeba_aregawi.jpeg","thumbnail_url":"\/images\/bagallery\/gallery-93\/thumbnail\/category-1\/abeba_aregawi.jpeg","title":"Abeba Aregawi","short":"","alt":"abeba aregawi","description":"","link":"","video":"","settings":null,"likes":0,"imageId":"6","target":"blank","lightboxUrl":"abeba-aregawi","watermark_name":"abeba_aregawi.jpeg","hideInAll":0,"suffix":""}

• World record holder in short track – Semen Elistratov
• Olympic champion figure skater – Ekaterina Bobrova
• Racing cyclist from team Katyusha – Eduard Varganov
• World champion weightlifter Aleksey Lovchev
• World champion runner from Sweden – Abeba Aregawi

Although professor Michael Joyner of the Mayo Clinic expressed some skepticism that it was a real hardcore athletic Biohack: 

"Evidence is lacking for many compounds believed to enhance athletic performance. Its use has a sort of urban legend element and there is not much out there that is clearly that effective. I would be shocked if this stuff [meldonium] had an effect greater than caffeine or creatine...”

Research

On Pubmed, you can find 25 clinical trials which evaluated it in humans. To summarize the findings

• The most recent trial done in 2016 evaluated it in healthy Chinese people. The study called Mildronate is an agent for cardioprotection and neuroprotection.
• A study of 49 patients called it an Adaptogen and found that it made the Russian winter a bit more sufferable and improved quality of life.
• It aids recovery from myocardial ischemia.
• Another 2014 study of middle-aged and elderly evaluated the effect of oxidative stress on meldonium, hemodynamics and quality of life of patients with cardiovascular disease (CVD) in extreme climatic conditions (summer heat). It also concluded that it had an adaptogenic effect, it improved response to oxidative stress 
• A recent trial of 140 patients Early use of meldonium decreases probability of emergence of fatal arrhythmias and improves prognosis of hospital stage of rehabilitation of patients with acute coronary syndrome.

The evidence is better for its physical performance enhancement effects, evidence of its potency as a cognitive enhancer is not significant. It won't be my go-to Russian smart drug.

Side Effects

The recent Chinese study reported No serious adverse events were observed. A 2015 trial of 67 Russians agreed No side effects were registered during the course of mildronate treatment.

Like Semax and Cerebrolysin, Mildronate is on the Russian List of Vital & Essential Drugs.

Country of origin: Latvia

Scientific overview

There are 4 DIVAZA® clinical trials; the most recent completed in 2017 included 126 Russian patients with mild to moderate cognitive disorders. A 2016 study administered it to 60 middle-aged to elderly patients for 12 weeks...

Divaza significantly improved cognitive status as assessed with MMSE and reduce anxiety symptoms according to the Hamilton anxiety scale after three weeks of treatment. This statistically significant trend was observed after 12 weeks treatment. Correction of cognitive and emotional capacities contributed to a significant increase in quality of life (SS-QOL) in patients of the main group. The drug was well-tolerated by all patients and had no side-effects.

So it manifested classic Nootropic effects for the elderly and impaired; enhanced cognition, anxiety reduction, and improved quality of life - so I would expect it to have performance-enhancing effects in otherwise healthy, younger people. The most exhaustive clinical trial of DIVAZA® was completed in 2020, totaling over 2500 chronic cerebral ischemia patients, it demonstrated the drug as an effective brain power Nootropic.

Divaza improved cognitive functions of patients in each age group... In the study, we observed the efficacy of Divaza for the treatment of [cognitive disorder]: a therapy contributed to an increase in the mean [Montreal Cognitive Assessment] score and the positive dynamics in the number of patients with cognitive improvement.

The trial gives us some dosage and usage guidelines...

Patients received Divaza (2 tablets 3 times per day for 12 weeks).

About

DIVAZA® - is effective in improving cognitive functions, reducing signs of mental and physical asthenia, increasing activity and motivation, resolving asthenic symptoms of the autonomic nervous system and restoring psychic performance, alleviating headache and vertigo, decreasing emotional lability, anxiety and depression, and ameliorating sleep disturbances. It has good tolerability, does not cause side effects and is compatible with any other medications that may be used concomitantly. Divaza is available in a convenient form, i.e. orally disintegrating tablets.

USES

• Mild to moderate cognitive disorders.
• Neurodegenerative and cerebrovascular disorders.
• Antihypoxant and antioxidant activity.
• Reduction of the lipid peroxidation process.

As a vain biohacker, I'm always eager to try things that might make me look better or younger. EXOMITIN®, a regenerative hydrogel powered by the antioxidant plastoquinone, I've been eager to try since I researched its active ingredient, SKQ1 a Smart Mitochondrial Antioxidant and Longevity Game Changer.

There are four items of scientific research published on SKQ1's effect on the skin, several animal studies have demonstrated it as effective in healing and restoring skin.

About

Regenerative Antioxidant Hydrogel with the Anti-Aging Gamechanger SkQ1

EXOMITIN® (Regenerative Antioxidant Hydrogel SkQ1) provides special skincare after a negative thermal or mechanical impact, as well as for the care of problematic and damaged skin. Thanks to the innovative formula, the mitochondrial antioxidant SkQ1 (Skulachev ions) has a protective and soothing effect in the occurrence of various kinds of irritation, redness, and dryness of the skin. Hydrogel Exomitin® enhances the antioxidant defense of skin cells and improves its regenerative functions. Thanks to the innovative formula, the mitochondrial antioxidant SkQ1 has a protective and soothing effect in the occurrence of various kinds of irritation, redness, and dryness of the skin.

USES

• Effective Skin Cell Protection
• Restores, Regenerates, and Soothes Skin
• Increases Antioxidant Protection
• Increases its Resistance to the Effects of Adverse Environmental Factors