Pharmaceuticals

The Anti-COVID Antibiotic

In the very turbulent first year of this decade AZITHROMYCIN®, a 40-year-old drug has almost become a household name being the subject of over 66,000 news media articles. Is it being unfairly demonized because it's a cheap, effective drug competing with big pharma's patented +$2000 drug, Remdesivir? Does it deserve a place in the antifragile Biohacker's anti-COVID tool chest?

The distinguishing characteristic of Cerebrolysin is that you inject it (intramuscularly as opposed to intravenously, which should make you feel like less of a junky). It can increase your Brain-Derived Neurotrophic Factor by as much as 600%.

This is a peptide-based Nootropic with an impressive 165 human studies referenceable on Pubmed, over 30 human clinical trials have been done with Cerebrolysin in the past 10 years alone which is an appreciable amount of research. Piracetam has approximately the same amount of recent human trials. It is now hard to believe, but Cerebrolysin – perhaps the most efficient peptide nootropic – was developed when the scientific community had a very limited understanding of how the central nervous system works.

Cortexin® is a mixture of neuropeptide fractions, amino acids, vitamins, and minerals. It has a pronounced but subtle positive effect on the brain.

Similar to Cerebrolysin, Cortexin is based on neuropeptides and amino acids. the pharmacological difference is that Cortexin has significantly more peptide fractions and fewer amino acids. Another notable difference is that it doesn't come from pig brains, so it may be a better option for people who really want to inject their Nootropics but just don't like pigs.

Peptide overview

This "smart peptide" is a genetic hack for enhanced immunity, which is particularly helpful to the elderly for treating or preventing...

• Chronic and acute inflammatory diseases.
• Viral respiratory infections; pneumonia, bronchitis, sore throats, ear infections, and sinusitis.
• Autoimmune diseases.
• Cystitis, Pyelonephritis, Prostatitis, and Adnexitis. 
• Systemic connective tissue disease.
• Along with recovering from chemotherapy.

Crystagen differs from other immune medicines and biohacks I've discussed, it's more a tool for restoration than prevention. It's used to rebuild a compromised immune system.

Scientific overview

There are 4 DIVAZA® clinical trials; the most recent completed in 2017 included 126 Russian patients with mild to moderate cognitive disorders. A 2016 study administered it to 60 middle-aged to elderly patients for 12 weeks...

Divaza significantly improved cognitive status as assessed with MMSE and reduce anxiety symptoms according to the Hamilton anxiety scale after three weeks of treatment. This statistically significant trend was observed after 12 weeks treatment. Correction of cognitive and emotional capacities contributed to a significant increase in quality of life (SS-QOL) in patients of the main group. The drug was well-tolerated by all patients and had no side-effects.

So it manifested classic Nootropic effects for the elderly and impaired; enhanced cognition, anxiety reduction, and improved quality of life - so I would expect it to have performance-enhancing effects in otherwise healthy, younger people. The most exhaustive clinical trial of DIVAZA® was completed in 2020, totaling over 2500 chronic cerebral ischemia patients, it demonstrated the drug as an effective brain power Nootropic.

Divaza improved cognitive functions of patients in each age group... In the study, we observed the efficacy of Divaza for the treatment of [cognitive disorder]: a therapy contributed to an increase in the mean [Montreal Cognitive Assessment] score and the positive dynamics in the number of patients with cognitive improvement.

The trial gives us some dosage and usage guidelines...

Patients received Divaza (2 tablets 3 times per day for 12 weeks).

About

DIVAZA® - is effective in improving cognitive functions, reducing signs of mental and physical asthenia, increasing activity and motivation, resolving asthenic symptoms of the autonomic nervous system and restoring psychic performance, alleviating headache and vertigo, decreasing emotional lability, anxiety and depression, and ameliorating sleep disturbances. It has good tolerability, does not cause side effects and is compatible with any other medications that may be used concomitantly. Divaza is available in a convenient form, i.e. orally disintegrating tablets.

USES

• Mild to moderate cognitive disorders.
• Neurodegenerative and cerebrovascular disorders.
• Antihypoxant and antioxidant activity.
• Reduction of the lipid peroxidation process.

This is an Interferon immune-hack and anti-viral that you take nasally, as drops, or ointment.

In this brave "new normal" decade immune hacks are deservedly on the radar of sapient biohackers. It shouldn't replace Vitamin-D in your medicine cabinet but tools like this have a place in the bio-prepper's armamentarium.

About product

✔ Boosts connective tissue production within muscles, bones, cartilage and ligaments to improve mobility and flexibility, reduce inflammation and promote pain relief
✔ Aids skin cell repair for stronger skin, improves skin elasticity and hydration, and helps slow down skin aging
✔ Helps improve gut health and treat intestinal permeability; promotes heart health and improves metabolism
✔ Supports keratin production for stronger, smoother hair growth and a tighter hair

from goneuroactive.com

About NeuroActive

This is a new vendor that I'm pleased to be working with serving European Biohackers, a good group of folks that sometimes have trouble getting their hands on quality Nootropics and anti-aging stuff, especially since Brexit and COVID policies have made importing packages even trickier in the European Union. Good news, NeuroActive is based in the EU (actually, they are in Bulgaria where I live) so they can deliver reliably here on the continent minimizing the hassle of paperwork and negotiating with import office bureaucrats. 

Biohacker Review: Memantine Makes Caffeine Great Again!

I did one little blue tablet in the morning along with a capsule of Uridine, 10 milligrams of Noopept, and my adaptogenic herbs. Then I went to my favorite cafe to hang out and work on my laptop; I usually drink two large cafe Americanos, about 45 minutes later halfway through my first coffee memantine's effects were becoming quite noticeable;

• I was quite energetic and motivated.
• I was pretty creative and in a good mood.
• I ordered a second coffee but only drank half of it as I felt pretty wired.
• After working several hours I took a little break to read a book. I found the book very engrossing and intellectually stimulating - I had trouble putting it down!
• I noticed that day that my vision was just a little impaired, which is not good because my eyes are pretty bad, to begin with.
• By the end of the day, though I had mixed feelings about Memantine, I felt quite frazzled and socially awkward. My motor control seemed a little off as well, and my typing was a little inaccurate, although I was motivated to work pretty late into the night.

In the future, I'll isolate Memantine and caffeine or Memantine and Racetams.

A Neuropeptide-Powered Nootropic

MEMOPROVE® is an innovative European Nootropic that, as its name implies, enhances memory and cognition. Whether you're a grad student, a hardworking professional, or just sick of forgetting where you left your keys - Neuropeptides can give you an edge. The active peptide in this Nootropic is N-PEP-12™.

METFORMIN® (Glucophage) - is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in patients with type 2 diabetes.

Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb.

USES

• Control High Blood Sugar Levels
• First-line Treatment of Type 2 Diabetes
• First-Line Treatments for Infertility in Women With Polycystic Ovary Syndrome
• Improves Overall Wellbeing
• May Reduce Insulin Requirement in Type 1 Diabetes