Pharmaceuticals

A Neuropeptide-Powered Nootropic

MEMOPROVE® is an innovative European Nootropic that, as its name implies, enhances memory and cognition. Whether you're a grad student, a hardworking professional, or just sick of forgetting where you left your keys - Neuropeptides can give you an edge. The active peptide in this Nootropic is N-PEP-12™.

This is an Interferon immune-hack and anti-viral that you take nasally, as drops, or ointment.

In this brave "new normal" decade immune hacks are deservedly on the radar of sapient biohackers. It shouldn't replace Vitamin-D in your medicine cabinet but tools like this have a place in the bio-prepper's armamentarium.

Biohacker Review: Memantine Makes Caffeine Great Again!

I did one little blue tablet in the morning along with a capsule of Uridine, 10 milligrams of Noopept, and my adaptogenic herbs. Then I went to my favorite cafe to hang out and work on my laptop; I usually drink two large cafe Americanos, about 45 minutes later halfway through my first coffee memantine's effects were becoming quite noticeable;

• I was quite energetic and motivated.
• I was pretty creative and in a good mood.
• I ordered a second coffee but only drank half of it as I felt pretty wired.
• After working several hours I took a little break to read a book. I found the book very engrossing and intellectually stimulating - I had trouble putting it down!
• I noticed that day that my vision was just a little impaired, which is not good because my eyes are pretty bad, to begin with.
• By the end of the day, though I had mixed feelings about Memantine, I felt quite frazzled and socially awkward. My motor control seemed a little off as well, and my typing was a little inaccurate, although I was motivated to work pretty late into the night.

In the future, I'll isolate Memantine and caffeine or Memantine and Racetams.

Biohacker Review: Overcoming Sleep Deprivation

I hadn't used Modafinil in quite some time, I'd just received an assortment of Eurogics which I decided to use to offset a night of bad sleep. Which I don't recommend generally, Nootropics should not be used regularly to cope with insomnia, but I suffer from insomnia infrequently and Modafinil can really make a big difference when you're sleep-deprived.

My personal policy on sleep deprivation is that I wake up early, get to work, and do my best to power through the day. I emerged from light and dissatisfying slumber around 5:30 AM after tossing and turning for hours while thoughts raced through my mind. Modafinil typically takes an hour or sometimes two to kick in for me, so I took a full 200-milligram capsule of MODAWAKE® and tried to go back to sleep. The Modafinil kicked in as expected, it's a kind of cool sensation to feel the Modafinil begin to take effect as you are halfway between the dream world and waking life. I cuddled with my wife for a bit and got up.

My thoughts on Mifepristone, the Abortion Pill, Up to 98% effective when used within 8 weeks of pregnancy.

I have not nor do I anticipate using it to have an abortion. I also realize it's a little weird for me as a guy to be doing a video about women's health. However, it's actually relevant to the other sex and contraception Biohacks I've discussed.

And it's consistent with my moral philosophy, I'll explain why later...

Mildronate modulates and improves the function of the heart which has a number of downstream performance-enhancing effects both for our physical and mental capacities.

Meldonium, or Mildronate, is prescribed to treat “different heart and vascular diseases,” according to the Latvian manufacturing company’s website, though it also notes that the drug can improve the “physical capacity” of healthy people. It increases blood flow, which improves exercise capacity in athletes.

Performance Enhancer

Off – label use of Meldonuim in healthy people: increasing exercise tolerance, learning, memory, and even sexual function. One athletic Biohacker reported enthusiastically

"I play ice hockey, tennis and I do weights training and yoga. I have personally taken Meldonium... before weights and yoga training... before ice hockey, and the benefits are immediate : more energy, no hunger, feeling light, as if my body was not heavy, also feeling really concentrate and aware and brain's functions seems enhanced. I could also add that this drug, make you not wanna lose, seems like it has a mental effect that keep you pushing more and refusing to lose or giving up and makes you wanna give your best until the end even in a losing game/match up."

Banned from the Olympics

Wada (World Anti-Doping Agency) found “evidence of it's use by athletes with the intention of enhancing performance” by virtue of carrying more oxygen to muscle tissue.

The decision to add Meldonium to the banned list was approved on September 16th, 2015, and it came into effect on January 1st, 2016. Wada had spent the previous year monitoring the drug before adding it to the banned list.

Meldonium gained popularity after Maria Sharapova, a famous tennis player, from Russia, said that she has been taking this drug for the last 10 years for health reasons. Also, a number of other world and Olympic champions admitted to taking it...

Pharmaceuticals - Page 2 - Limitless Mindset

Semen Elistratov

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Maria Sharapova

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Ekaterina Bobrova

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Eduard Varganov

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Aleksey Lovchev

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Abeba Aregawi

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• World record holder in short track – Semen Elistratov
• Olympic champion figure skater – Ekaterina Bobrova
• Racing cyclist from team Katyusha – Eduard Varganov
• World champion weightlifter Aleksey Lovchev
• World champion runner from Sweden – Abeba Aregawi

Although professor Michael Joyner of the Mayo Clinic expressed some skepticism that it was a real hardcore athletic Biohack: 

"Evidence is lacking for many compounds believed to enhance athletic performance. Its use has a sort of urban legend element and there is not much out there that is clearly that effective. I would be shocked if this stuff [meldonium] had an effect greater than caffeine or creatine...”

Research

On Pubmed, you can find 25 clinical trials which evaluated it in humans. To summarize the findings

• The most recent trial done in 2016 evaluated it in healthy Chinese people. The study called Mildronate is an agent for cardioprotection and neuroprotection.
• A study of 49 patients called it an Adaptogen and found that it made the Russian winter a bit more sufferable and improved quality of life.
• It aids recovery from myocardial ischemia.
• Another 2014 study of middle-aged and elderly evaluated the effect of oxidative stress on meldonium, hemodynamics and quality of life of patients with cardiovascular disease (CVD) in extreme climatic conditions (summer heat). It also concluded that it had an adaptogenic effect, it improved response to oxidative stress 
• A recent trial of 140 patients Early use of meldonium decreases probability of emergence of fatal arrhythmias and improves prognosis of hospital stage of rehabilitation of patients with acute coronary syndrome.

The evidence is better for its physical performance enhancement effects, evidence of its potency as a cognitive enhancer is not significant. It won't be my go-to Russian smart drug.

Side Effects

The recent Chinese study reported No serious adverse events were observed. A 2015 trial of 67 Russians agreed No side effects were registered during the course of mildronate treatment.

Like Semax and Cerebrolysin, Mildronate is on the Russian List of Vital & Essential Drugs.

Country of origin: Latvia

About product

✔ Boosts connective tissue production within muscles, bones, cartilage and ligaments to improve mobility and flexibility, reduce inflammation and promote pain relief
✔ Aids skin cell repair for stronger skin, improves skin elasticity and hydration, and helps slow down skin aging
✔ Helps improve gut health and treat intestinal permeability; promotes heart health and improves metabolism
✔ Supports keratin production for stronger, smoother hair growth and a tighter hair

from goneuroactive.com

About NeuroActive

This is a new vendor that I'm pleased to be working with serving European Biohackers, a good group of folks that sometimes have trouble getting their hands on quality Nootropics and anti-aging stuff, especially since Brexit and COVID policies have made importing packages even trickier in the European Union. Good news, NeuroActive is based in the EU (actually, they are in Bulgaria where I live) so they can deliver reliably here on the continent minimizing the hassle of paperwork and negotiating with import office bureaucrats. 

Scientific overview

There are 4 DIVAZA® clinical trials; the most recent completed in 2017 included 126 Russian patients with mild to moderate cognitive disorders. A 2016 study administered it to 60 middle-aged to elderly patients for 12 weeks...

Divaza significantly improved cognitive status as assessed with MMSE and reduce anxiety symptoms according to the Hamilton anxiety scale after three weeks of treatment. This statistically significant trend was observed after 12 weeks treatment. Correction of cognitive and emotional capacities contributed to a significant increase in quality of life (SS-QOL) in patients of the main group. The drug was well-tolerated by all patients and had no side-effects.

So it manifested classic Nootropic effects for the elderly and impaired; enhanced cognition, anxiety reduction, and improved quality of life - so I would expect it to have performance-enhancing effects in otherwise healthy, younger people. The most exhaustive clinical trial of DIVAZA® was completed in 2020, totaling over 2500 chronic cerebral ischemia patients, it demonstrated the drug as an effective brain power Nootropic.

Divaza improved cognitive functions of patients in each age group... In the study, we observed the efficacy of Divaza for the treatment of [cognitive disorder]: a therapy contributed to an increase in the mean [Montreal Cognitive Assessment] score and the positive dynamics in the number of patients with cognitive improvement.

The trial gives us some dosage and usage guidelines...

Patients received Divaza (2 tablets 3 times per day for 12 weeks).

About

DIVAZA® - is effective in improving cognitive functions, reducing signs of mental and physical asthenia, increasing activity and motivation, resolving asthenic symptoms of the autonomic nervous system and restoring psychic performance, alleviating headache and vertigo, decreasing emotional lability, anxiety and depression, and ameliorating sleep disturbances. It has good tolerability, does not cause side effects and is compatible with any other medications that may be used concomitantly. Divaza is available in a convenient form, i.e. orally disintegrating tablets.

USES

• Mild to moderate cognitive disorders.
• Neurodegenerative and cerebrovascular disorders.
• Antihypoxant and antioxidant activity.
• Reduction of the lipid peroxidation process.

METFORMIN® (Glucophage) - is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in patients with type 2 diabetes.

Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb.

USES

• Control High Blood Sugar Levels
• First-line Treatment of Type 2 Diabetes
• First-Line Treatments for Infertility in Women With Polycystic Ovary Syndrome
• Improves Overall Wellbeing
• May Reduce Insulin Requirement in Type 1 Diabetes