Limitless Mindset | Acquire Superhuman Mind Power & Hack Your Reality - Limitless Mindset How to become 'Limitless' in real life: maximize brain power, superpower memory, cognitive abilities, increase energy, and learn faster. Master influence, persuasion and communication skills to dominate in business, sales, social situations, dating and life. Sun, 26 Oct 2014 02:48:44 +0000 Joomla! - Open Source Content Management en-gb Sulbutiamine by New Star Nootropics

Sulbutiamine is a synthetic derivative of thiamine with some interesting pharmacological properties.

]]> (Jonathan Roseland) Supplements & Drugs Wed, 15 Oct 2014 22:16:00 +0000
The testosterone mimetic properties of icariin

To evaluate the testosterone mimetic properties of icariin.

Forty-eight healthy male Sprague-Dawley rats at the age of 15 months were randomly divided into four groups with 12 rats each: the control group (C), the model group (M), the icariin group (ICA) and the testosterone group (T). The reproductive system was damaged by cyclophosphamide (intraperitoneal injection, 20 mg/kg x day) for 5 consecutive days for groups M, ICA and T, at the sixth day, ICA (gastric gavage, 200 mg/kg x day) for the ICA group and sterandryl (subcutaneous injection, 5 mg/rat . day) for the T group for 7 consecutive days, respectively. The levels of serum testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), serum bone Gla-protein (BGP) and tartrate-resistant acid phosphatase activity in serum (StrACP) were determined. The histological changes of the testis and the penis were observed by microscope with hematoxylin-eosin (HE) staining and terminal deoxynucleotidyl transferase biotin-dUTP-X nick end labeling (TUNEL), respectively.

(1) Icariin improved the condition of reproductive organs and increased the circulating levels of testosterone. (2) Icariin treatment also improved the steady-state serum BGP and might have promoted bone formation. At the same time, it decreased the serum levels of StrACP and might have reduced the bone resorption. (3) Icarrin suppressed the extent of apoptosis of penile cavernosal smooth muscle cells.

Icariin has testosterone mimetic properties and has therapeutic potential in the management of hypoandrogenism.

]]> (Jonathan Roseland) Scientific Studies & Papers Wed, 15 Oct 2014 03:53:00 +0000
Icariin - 5 Grams (98% Pure)

Icariin is a flavonol, found in several species of plants in the Epimedium family which are commonly known as Horny Goat Weed or Yin Yang Huo.

Extracts from these plants are reputed to produce endurance-promoting effects and may aid healthy sexual function. Icariin also supports mental focus and bone strength.

]]> (Jonathan Roseland) Supplements & Drugs Wed, 15 Oct 2014 03:24:00 +0000
Inhibitory effect of icariin on acetylcholinesterase

Acetylcholinesterase (AChE) inhibitors are mainly used in the treatment of Alzheimer's disease (AD). The inhibitory effect of icariin on the activity of AChE was investigated by inhibition kinetics. The binding interaction and binding sites between icariin and AChE were also studied by using fluorimetry and molecular docking, respectively. The results showed that icariin could potently inhibit the activity of AChE, the IC50 value was determined to be 3.50 x 10(-8) mol x L(-1), and the determined IC50 value to tacrine was 0.75 x 10(-8) mol x L(-1). Kinetic analyses showed that icariin is a reversible and mixed type AChE inhibitor. The inhibition constants K1 and K(IS) were determined to be 2.67 x 10(-8) and 4.43 x 10(-8) mol x L(-1), respectively. Icariin binds selectively to the AChE peripheral anionic site via hydrogen bonds and Van der Waals forces.

]]> (Jonathan Roseland) Scientific Studies & Papers Tue, 14 Oct 2014 03:44:00 +0000
The genus Epimedium: an ethnopharmacological and phytochemical review.

Epimedium (Berberidaceae), is a genus of about 52 species in the family Berberidaceae, which also known as Rowdy Lamb Herb, Xianlinpi, Barrenwort, Bishop's Hat, Fairy Wings, Horny Goat Weed, and Yangheye or Yin Yang Huo (Chinese: ). Many plants have been proven to possess efficacy on sexual dysfunction and osteoporosis in traditional Chinese medicine (TCM). The paper reviews the ethnopharmacology, the biological activities and the correlated chemical compounds of Epimedium species. More than 260 compounds have been isolated; among them prenyl-flavonoids are the major constituents and also important chemotaxonomic markers. Modern pharmacology studies and clinical practice demonstrated that Epimedium and its active compounds possess wide pharmacological actions, especially in strengthening yang, hormone regulation, anti-osteoporosis, immunological function modulation, anti-oxidation and anti-tumor, anti-aging, anti-atherosclerosis and anti-depressant activities. Currently, effective monomeric compounds or active parts have been screened for pharmacological activity from Epimedium in vivo and in vitro.

]]> (Jonathan Roseland) Scientific Studies & Papers Tue, 14 Oct 2014 03:36:00 +0000